Ahmed Hamdy,Wayne Rothbaum,Raquel Izumi,Brian Lannutti,Todd Covey,Roger Ulrich,Dave Johnson,Tjeerd Barf,Allard Kaptein
申请号：
US15319740
公开号：
US09949971B2
申请日:
2015.06.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Therapeutic combinations of a Janus kinase-2 (JAK-2) inhibitor, a Brutons tyrosine kinase (BTK) inhibitor, and/or a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the γ- and δ-isoforms and selective for both γ- and δ-isoforms, are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of (1) a PI3K-δ inhibitor and a BTK inhibitor, (2) a JAK-2 inhibitor and a BTK inhibitor, or (3) a JAK-2 inhibitor, PI3K-δ inhibitor, and BTK inhibitor, and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer.
