Edward Thein Htun van der Horst,Austin L. Gurney,Timothy Charles Hoey,Maureen Fitch Bruhns,Fumiko Takada Axelrod
申请号：
US13797374
公开号：
US09132189B2
申请日:
2013.03.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia.
