ЭСПОЗИТО Люк А. (US),ХАДСОН Ф. Майкл (US),ЛЭЙК Томас (US),КАММИНГЗ Джоел (US),ВАЙГЕЛЕ Манфред (US),СНОУ Алан Д. (US),ЛАРСЕН Лесли (NZ)
申请号：
RU2011117544/04
公开号：
RU2011117544A
申请日:
2009.06.26
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. The compound of the formula:! ! and its pharmaceutically acceptable salts. ! 2. The compound according to claim 1, designed to inhibit the formation, deposition, accumulation or sustainable existence of aggregates of Aβ-amyloid or α-synuclein. ! 3. The compound according to claim 1, intended for the treatment of β-amyloid diseases and synucleinopathies in mammals suffering from these diseases. ! 4. The compound according to claim 3, where the β-amyloid disease is selected from the group of diseases consisting of Alzheimer's disease, Down syndrome, hereditary cerebral hemorrhage with Dutch type amyloidosis and cerebral β-amyloid angiopathy. ! 5. The compound according to claim 3, where the β-amyloid disease is Alzheimer's disease. ! 6. The compound according to claim 3, where the synucleinopathy is selected from the group consisting of Parkinson’s disease, Parkinson’s family disease, Levi’s disease, a variant of Alzheimer's disease with Levi’s bodies, dementia with Levi’s bodies, multiple systemic atrophy and Guam’s parkinsonism-dementia complex. ! 7. The compound according to claim 3, where the synucleinopathy is Parkinson's disease. ! 8. The compound according to claim 1, intended to improve motor activity in mammals suffering from synucleinopathy. ! 9. The compound according to claim 1, designed to stop the progression of motor disorders in mammals suffering from Parkinson's disease. ! 10. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable excipient. ! 11. The use of a compound according to claim 1 for the manufacture of a medicament for the treatment of β-amyloid diseases and synucleinopathy in mammals suffering from these diseases. ! 12. Note1. Соединение формулы: ! !и его фармацевтически приемлемые соли. ! 2. Соединение по п.1, предназначенное для ингибирования образования, отложения, накопления или устойчивого существования агрегатов Аβ-амилоида или α-синуклеина. ! 3. Соединение по п.1, предназнач
