A compound, pharmaceutical composition, and methods for inhibiting the formation, deposition, accumulation, or persistence of amyloid abeta or alpha-synuclein aggregates, to treat a beta-amyloid disease or synucleinopathy in a suffering mammal, to improve performance. in a mammal suffering from a synucleinopathy, and to halt the progression of motor deficits in a mammal suffering from parkinson's disease
LUKE A. ESPOSITO,F. MICHAEL HUDSON,THOMAS LAKE,JOEL CUMMINGS,MANFRED WEIGELE,ALLAN D.SNOW,LESLEY LARSEN
申请号：
BRPI0920687
公开号：
BRPI0920687A2
申请日:
2009.06.26
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of &bgr；-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
