DERIVATIVES OF 5-(HETERO)ARYLPYRAZOL-3-CARBOXYLIC AMIDE OR 1-(HETERO)ARYLTRIAZOL-4-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS

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专利权人:

Proteostasis Therapeutics; Inc.

发明人:

Cecilia M. Bastos,Benito Munoz,Bradley Tait

申请号：

US15539401

公开号：

US20180327363A1

申请日:

2015.12.23

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IVa), (Va), (IV), or (V) can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.

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http://www.ckcest.cn/home/