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MICELLE COMPOSITION FOR NUCLEIC ACID DELIVERY USING TEMPERATURE-SENSITIVE POLYMER AND METHOD FOR PRODUCING SAME
专利权人:
The University of Tokyo
发明人:
Kazunori KATAOKA,Yasutaka ANRAKU,Kanjiro MIYATA,Meng ZHENG,Shigehito OSAWA
申请号:
US15575716
公开号:
US20180289835A1
申请日:
2016.05.20
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Provided are a micelle composition for nucleic acid delivery using a temperature-sensitive polymer, and a method for producing the micelle. For example, provided is a polyion complex comprising a temperature-sensitive copolymer and a nucleic acid, wherein the temperature-sensitive copolymer comprises a cationic block and a temperature-sensitive block, the cationic block optionally carrying a hydrophilic block linked thereto, and the polyion complex is obtained by mixing the temperature-sensitive copolymer with the nucleic acid under temperature conditions equal to or lower than the lower critical solution temperature (LCST) of the temperature-sensitive copolymer.
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