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NOVEL EPITOPE FOR SWITCHING TO TH1 CELL AND USE THEREOF
专利权人:
发明人:
Byoung S. Kwon,Seoung-Joo Lee
申请号:
US15866042
公开号:
US20180362612A1
申请日:
2018.01.09
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to a novel epitope that converts T cell to type 1 helper T (TH1) cell. Specifically, the present invention relates to an epitope constituting the 56th to 65th amino acids (SEQ ID No.2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH1 cell and a method for converting T cell to TH1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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