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Antibody specifically recognizing an epitope for switching to Th2 cell and a method for converting T cell to type 2 helper T cell using the same
专利权人:
发明人:
Byoung Se Kwon
申请号:
US13861675
公开号:
US09255152B2
申请日:
2013.04.12
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to a novel epitope to convert T cell to type 2 helper T (TH2) cell. Specifically, the present invention relates to an epitope constituting the 20th to 30th amino acids (SEQ ID No. 2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH2 cell and a method of conversion, a pharmaceutical composition comprising the antibody for preventing or treating autoimmune disease, and a method for treating autoimmune disease using the antibody.
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