Provided herein are therapeutic prodrug compositions which may be delivered to a patient via an injectable emulsion, comprising a therapeutic drug linked to a peptide that is efficiently and specifically cleaved by a selected protease associated with a cell proliferative disorder, including cancer cells, for example, prostate, liver or breast cancer cells, in a patient. Also provided herein are methods of treating cell proliferative disorders, including cancers, with the therapeutic prodrug compositions.una composición farmacéutica adecuada para administración intravenosa que comprende un profármaco que comprende un fármaco terapéuticamente activo que comprende un sesquiterpeno-gamma lactosa, uno de sus análogos o derivados, y un péptido que comprende una secuencia de aminoácidos que tiene un sitio de escisión específico para una proteasa asociada con un trastorno proliferativo celular.
