BAUDOUX, GUY JEAN MARIE FERNAND PIERRE,BLAIS, NORMAND,CYR, SONYA L.,RHEAULT, PATRICK,RUELLE, JEAN LOUIS
申请号：
PE0021682011
公开号：
PE15412012A1
申请日:
2010.06.24
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to an antigen sincicio Respiratory virus (RSV) comprising a recombinant polypeptide soluble F Protein with two Domains F1 and F2 a polypeptide of RSV F Protein F2 Domain comprises 26 - 105 amino acids and \/ or F1 Domain comprises amino acids 137 - 516 po Lipeptido precursor of F Protein of reference (FO) of SEQ ID no: 2.The Antigen of RSV is selected from: (a) a polypeptide comprising SEQ ID no: 22 (b) a polypeptide encoded by SEQ ID no: 21, (c) a polypeptide with at least 95% Sequence Identity to SEQ ID no: 22.The F Protein is a soluble polypeptide selected Modification of: i) adding an Amino Acid Sequence with a heterologous trimerizacion Domain (ii) deletion with at least a Furin Site of digestion (iii) deletion of a site not Furin digestion (iv) deletion of one Or more amino acids pep27 Domain and (V) at least one amino acid replacement or addition of a HydroFilico in a Hydrophobic domain of the extracellular domain of F Protein. Also referred to a Nucleic Acid, a Vector and a host cell. Said Antigen is a component of an immunogenic composition being useful for the treatment and \/ or prevention of RSV infectionSE REFIERE A UN ANTIGENO DE VIRUS DE SINCICIO RESPIRATORIO (RSV) RECOMBINANTE QUE COMPRENDE UN POLIPEPTIDO DE PROTEINA F SOLUBLE CON DOS DOMINIOS F1 Y F2 DE UN POLIPEPTIDO DE PROTEINA F DE RSV EL DOMINIO F2 COMPRENDE LOS AMINOACIDOS 26-105 Y/O EL DOMINIO F1 COMPRENDE LOS AMINOACIDOS 137-516 DEL POLIPEPTIDO PRECURSOR DE PROTEINA F DE REFERENCIA (FO) DE SEQ ID NO: 2. EL ANTIGENO DE RSV SE SELECCIONA DE: a) UN POLIPEPTIDO QUE COMPRENDE SEQ ID NO:22 b) UN POLIPEPTIDO CODIFICADO POR SEQ ID NO: 21, c) UN POLIPEPTIDO CON AL MENOS 95% DE IDENTIDAD DE SECUENCIA A SEQ ID NO: 22. EL POLIPEPTIDO DE PROTEINA F SOLUBLE COMPRENDE UNA MODIFICACION SELECCIONADA DE: i) ADICION DE UNA SECUENCIA DE AMINOACIDOS CON UN DOMINIO DE TRIMERIZACION HETEROLOGO ii) DELECION CON AL MENOS UN SITIO DE DIGESTION DE FURINA iii) DELECION DE UN SITIO DE NO DIGESTION DE FURINA iv) DE
