PYRAZOLO [3,4-D] PYRIMIDINES COMME INHIBITEURS DE SKF

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专利权人:

LEAD DISCOVERY SIENA S.R.L.

发明人:

BOTTA, MAURIZIO,ANGELUCCI, ADRIANO,DREASSI, ELENA,SCHENONE, SILVIA,TINTORI, CRISTINA,VIGNAROLI, GIULIA

申请号：

CA2965734

公开号：

CA2965734A1

申请日:

2015.10.29

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine derivatives of formula I and IV able to target the Src family kinases (SFKs) such as Src, Fyn and Hck tyrosine kinases as well as Abl tyrosine kinase and uses and method of preparation thereof. In particular, the compounds of the invention are for use in the treatment and/or prevention of cancer, such as neuroblastoma (NB) or glioblastoma multiforme (GBM) or for use in the treatment and/or prevention of neurodegenerative diseases such as taupathies.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/