Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.本發明描述結合骨硬化素或骨硬化素及TNF之蛋白質,以及其在用於治療、預防及診斷骨硬化素相關疾病及用於偵測細胞、組織、樣本及組合物中之骨硬化素或骨硬化素及TNF之組合物及方法中的用途。