Общество с ограниченной ответственностью "Научно-внедренческий центр "Агроветзащита" (RU)
发明人:
Енгашев Сергей Владимирович (RU),Германов Сергей Борисович (RU),Енгашева Екатерина Сергеевна (RU),Новиков Денис Дмитриевич (RU),Хомишин Дмитрий Владимирович (RU),Гладушко Яна Юрьевна (RU),Тухфатова Ре
申请号：
RU2015107166
公开号：
RU2015107166A
申请日:
2015.03.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A liquid homogeneous phase transdermal pharmaceutical compositions for providing the absorption of biologically active substances through the skin of an animal in the absence of the stimulating effect of having organoleptic and physico-chemical properties, preventing slizyvanie animals and having a pH value ranging from 4 to 6, comprising a low viscosity mixture of (with viscosity less than 5 cP at 20 ° C) at least one ether solvent and at least one amide solvent and dissolving therein a highly viscous mixture penetran s (with viscosity greater than 100 centipoise at a temperature of the animal skin), wherein the penetrant mixture contains: a) an amide component of the total formulyAcNRCH (CHX) CHYgdeR = H, saturated or unsaturated, aliphatic or heterocyclic radical Ac = RCO- or ArCO-, wherein R - saturated or unsaturated, aliphatic or heterocyclic or oxyaliphatic radical, Ar - aromatic radical n = 0 ÷ 4 X = H, OH, oR Y = OH, oR, NRR wherein R, R-, saturated or unsaturated aliphatic radicals, R, R- H, saturated or unsaturated aliphatic radikaly.b) or polyoxyethylated polioksipropilirova nny phenol of the general formula HO (CHRCHO) ArgdeAr - a substituted or unsubstituted aromatic radical n = 2-27 R = H, CH c) polyoxyethylated alcohol of general formulyHO (CHCHO) RgdeR - aliphatic or alicyclic saturated or unsaturated radical n = 2 -27 d) ether of general formula RORgdeR - aliphatic saturated or unsaturated radical R - aliphatic saturated or unsaturated radical, or heterocyclic radical oxygen radicals polyhydric alcohol of the general formula -CH (CHOX) CHOYgdeX, Y - H, an aliphatic saturated or an unsaturated radical n = 0 ÷ 4 e ) A polyhydric alcohol of general formula RCH (X) CH (Y) CH (Z) wherein R - saturated or unsaturated,
