VAN GOOR FREDRICK F,NUMA MEHDI MICHEL JAMEL,BEAR BRIAN RICHARD,RUAH SARA S. HADIDA,MCCARTNEY JASON,ZHOU JINGLAN,MILLER MARK THOMAS,GROOTENHUIS PETER DIEDERIK JAN
申请号：
NZ60996208
公开号：
NZ609962A
申请日:
2008.11.12
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein is a use of (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide represented by structural formula shown herein in the manufacture of a medicament for treating male infertility or pancreatic insufficiency. Said compound is a modulator of ATP-Binding Cassette (&rsquoABC&rsquo) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and is also suitable for treating a condition, disease, or disorder selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, chronic obstructive pulmonary disease (COPD), dry-eye disease, and Sjögren&rsquos disease.
