Ruah Sara Hadida S,Miller Mark T,Numa Mehdi Michel Djamel,Zhou Jinglan,Van Goor Fredrick,Grootenhuis Peter D. J,Mccartney Jason,Bear Brian
申请号：
NZ71959808
公开号：
NZ719598A
申请日:
2008.11.12
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed herein is a use of an indol-cyclopropanecarboxamide derivative represented by structural formula shown herein in the manufacture of a medicament for treating a condition, disease, or disorder in a patient implicated by ABC transporter activity. Said compound is a modulator of ATP-Binding Cassette (’ABC’) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and is also suitable for treating a condition, disease, or disorder selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, chronic obstructive pulmonary disease (COPD), dry-eye disease, and Sjögren’s disease.
