НИТЦЕЛЬ Грегори П. (US),ГЭЛВИН Джефри Е. (US),ГАРРЕТ Джон Кейт (US),КЬЮЛОВИК Джеймс Р.II (US),РИКЕР Трейси Л. (US),СМАТЦЕР Меган Мари (US)
申请号：
RU2014140106
公开号：
RU2014140106A
申请日:
2013.04.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A multivalent immunogenic composition that contains a soluble portion of the whole-cell preparation Mycoplasma hyopneumoniae (M.hyo)； and swine circovirus type 2 antigen (PCV2), where the soluble part of M.hyo is essentially free of both (i) log G and (ii) immunocomplexes consisting of an antigen attached to an immunoglobulin. 2. A composition according to claim 1, wherein the soluble portion of the M.hyo preparation is treated with protein-A or protein-G before being added to the immunogenic composition. A composition according to claim 1 or 2, wherein the soluble portion of the M.hyo preparation and the PCV2 antigen are present as a ready-to-use liquid composition. The composition according to any one of paragraphs. 1 or 2, where the soluble portion of the M.hyo preparation contains at least one M.hyo protein antigen. 5. The composition of claim 4, wherein the soluble portion of the M.hyo preparation contains two or more M.hyo protein antigens. The composition according to any one of paragraphs. 1 or 2, where the composition elicits a protective immune response in a pig against M.hyo and PCV2.7. The composition according to any one of paragraphs. 1 or 2, wherein the PCV2 antigen is present as a hybrid type-1-type 2 circovirus, and said hybrid virus comprises an inactivated recombinant swine circovirus type 1 expressing an ORF2 swine type circovirus protein of type 2.8. The composition according to any one of paragraphs. 1 or 2, where the PCV2 antigen is present as a recombinant protein ORF2.9. The composition of claim 8, wherein the recombinant ORF2 protein is expressed by a baculovirus vector. The composition of claim 4, wherein the composition further comprises at least one additional antigen. The composition of claim 10, wherein at least one additional antigen protects against a microorganism that can cause disease in pigs. A composition according to claim 11, wherein the microorganism comprises a bacterium, a virus or protozoa. The composition of claim 12,
