НИТЦЕЛЬ Грегори П. (US),ГЭЛВИН Джефри Е. (US),ГАРРЕТ Джон Кейт (US),КЬЮЛОВИК Джеймс Р.II (US),РИКЕР Трейси Л. (US),СМАТЦЕР Меган Мари (US)
申请号：
RU2014140108
公开号：
RU2014140108A
申请日:
2013.04.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Trivalent immunogenic composition, which contains a soluble portion of the whole-cell preparation Mycoplasma hyopneumoniae (M. hyo)； swine circovirus antigen type 2 (PCV2)； and pig reproductive and respiratory syndrome virus antigen (PRRS), where the soluble portion of M. hyo is essentially free of both (i) IgG and (ii) immunocomplexes consisting of an antigen attached to an immunoglobulin. 2. The composition of claim 1, wherein the soluble portion of the M. hyo preparation is treated with protein A or protein G before being added to the immunogenic composition. The composition of claim 1, wherein the soluble portion of the M. hyo preparation and the PCV2 antigen are present as a ready-to-use liquid composition. The composition of claim 1, wherein the PRRS virus antigen is a genetically modified live virus. The composition of claim 4, wherein the genetically modified live PRRS virus is in the form of a lyophilized composition. The composition of claim 1, wherein the soluble portion of the M. hyo preparation contains at least one M. hyo protein antigen. The composition of claim 6, wherein the soluble portion of the M. hyo preparation contains two or more M. hyo protein antigens. The composition of claim 1, wherein the composition elicits a protective immune response in a pig against M. hyo, PCV2 and PRRS.9 virus. The composition of claim 1, wherein the PCV2 antigen is present as a hybrid type-1-type 2 circovirus, and said hybrid virus comprises an inactivated recombinant swine circovirus type 1 expressing an ORF2 protein of swine circovirus type 2.10. The composition of claim 1, wherein the PCV2 antigen is present as a recombinant protein ORF2.11. The composition of claim 10, wherein the recombinant ORF2 protein is expressed by a baculovirus vector. The composition of claim 1, wherein the composition further comprises an adjuvant. The composition of claim 12, wherein the adjuvant is selected from the group which1. Трехвалентная иммуногенная композиция, которая сод
