SUBSTITUTED 2-AZA-BICYCLO [2.2.1] HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

ANDERSKEWITZ, Ralf,OOST, Thorsten,PETERS, Stefan,GRAUERT, Matthias,GRUNDL, Marc,HAEBEL, Peter, Wilhelm,PAUTSCH, Alexander,BINDER, Florian,VINTONYAK, Viktor

申请号：

TN2015000381

公开号：

TN2015000381A1

申请日:

2015.08.31

申请国别(地区):

TN

年份:

2017

代理人:

摘要：

This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)- amides of formula (1) and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

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