LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME
BIONEER CORPORATION;SANOFI-AVENTIS KOREA CO., LTD.
发明人:
CHAE, JEIWOOK,PARK, HAN OH,YOON, PYOUNG OH,HAN, BORAM,KIM, HAN-NA,YUN, SUNG-IL,PARK, JUN HONG,KO, YOUNGHO,CHOI, GI-EUN,JUNG, JUNSOO,KIM, JAE EUN
申请号：
SG11201600076W
公开号：
SG11201600076WA
申请日:
2014.07.09
申请国别(地区):
SG
年份:
2016
代理人:
摘要：
There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
