The present invention addresses the problem of improving elution property and absorption property from an agent of (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl-1-pyrrolidinyl)-2-propene-1-one which is effective as an anti-tumor agent. Provided is a pharmaceutical composition containing (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl-1-pyrrolidinyl)-2-propene-1-one in combination with a C10-C18 alkyl group-containing sodium alkyl sulfate, particularly a sodium lauryl sulfate.本發明之課題在於改善作為抗腫瘤劑有效之(S)-1-(3-(4-胺基-3-((3,5-二甲氧基苯基)乙炔基)-1H-吡唑并[3,4-d]嘧啶-1-基-1-吡咯啶基)-2-丙烯-1-酮自製劑之溶出性及吸收性。本發明提供一種醫藥組合物，其以組合形式含有(S)-1-(3-(4-胺基-3-((3,5-二甲氧基苯基)乙炔基)-1H-吡唑并[3,4-d]嘧啶-1-基-1-吡咯啶基)-2-丙烯-1-酮與具有碳數10～18之烷基之烷基硫酸鈉、尤其是月桂基硫酸鈉。
