A compound of Formula I: ** Formula ** or pharmaceutically acceptable salts, hydrates or N-oxides thereof, wherein R1a and R1b are each independently selected from the group consisting of H and CH3； R2a is selected from the group consisting of H and F； and R2d is selected from the group consisting of H, C1-C4 alkoxy and C1-C4 haloalkoxy whose compound is not 2- (4- amino-3- (1H-imidazol-2-yl) -1H-pyrazole [3, 4-d] pyrimidin-1-yl) -1- (4- (4-chloro-3-methoxyphenyl) piperazin-1-yl) ethanone.Un compuesto de Fórmula I:**Fórmula** o sales farmacéuticamente aceptables, hidratos o N-óxidos de los mismos, en donde R1a y R1b se seleccionan cada uno independientemente del grupo que consiste en H y CH3； R2a se selecciona del grupo que consiste en H y F； y R2d se selecciona del grupo que consiste en H, alcoxi 10 C1-C4 y haloalcoxi C1-C4 cuyo compuesto no es 2-(4- amino-3-(1H-imidazol-2-il)-1H-pirazol[3,4-d]pirimidin-1-il)-1-(4-(4-cloro-3-metoxifenil)piperazin-1-il)etanona.
