Administration of the REG1 anticoagulation system

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专利权人:

Regado Biosciences; Inc.

发明人:

Tonkens, Ross M.,Rusconi, Christopher P.

申请号：

AU2013263868

公开号：

AU2013263868A1

申请日:

2013.12.02

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

#$%^&*AU2013263868A120140109.pdf#####H:\I\In,,Ievoven\NRPonbi\DCC\KLL\5858223_I.DOC-2/12/2013 ABSTRACT An improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host is provided based on weight adjusted or body mass index-adjusted dosing of 5 the components of the system to provide a desired pharmacodynamic response. In addition, a method of reversing activity of the aptamer to a desired extent is provided where an antidote dose is based solely on its relationship to the aptamer dose.FIGURE 18 11 5 100 I00 0 2 0 i @ 0 L. . . .. .8 %04 30.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 RB006 Dose (mg/BM I) Page 18 of 24

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