The invention relates to compositions and methods using various combinations of at least one of phytosterols, lunasin peptide and plant extracts, optionally in combination with at least one of, soy extracts, beta-glycolipides and different adjuvants such as, castor oil, polyethylene glycol, or beta-cyclo dextrin, for controlling blood sugar levels, altered insulin resistance and/or hepatic function in a subject, treating an immune related disorder, treating liver damage and restoring liver function, treating, preventing, ameliorating, reducing or delaying the onset of acute or chronic toxic effect of a drug, and for enhancing the therapeutic effect of a therapeutic agent in a subject.