菸鹼乙醯膽鹼受體之螺哌啶異位調節劑

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

CROWLEY, BRENDAN M.,科维力　布兰登　Ｍ,科維力　布蘭登　Ｍ,CAMPBELL, BRIAN T.,坎贝尔　布莱恩　Ｔ,坎貝爾　布萊恩　Ｔ,CHOBANIAN, HARRY R.,乔班尼安　哈利　Ｒ,喬班尼安　哈利　Ｒ,FELLS, JAMES I.,费欧斯　詹姆士　Ｉ,費歐斯　詹姆士　Ｉ,GUIADEEN, DEODIAL G.,古耶狄恩　迪欧戴尔　Ｇ,古耶狄恩　迪歐戴爾　Ｇ

申请号：

TW108114867

公开号：

TW202014419A

申请日:

2019.04.29

申请国别(地区):

TW

年份:

2020

代理人:

摘要：

The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.本發明係關於適用作α7 nAChR之調節劑的式I化合物、包含此類化合物之組合物及此類化合物用於預防、治療或改善疾病(尤其中樞神經系統之病症)的用途，該等病症係諸如阿茲海默氏病(Alzheimer's disease)、帕金森氏病(Parkinson's disease)及精神分裂症中之認知障礙以及L-DOPA誘發之運動困難及發炎。

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/