Problem to be solved: to provide a novel composition comprising a dual specificity polypeptide agent and a multiplex specific polypeptide agent.Solution: a multiplex specific polypeptide agent comprising at least one binding site that is specifically associated with the PD-1 molecule and a TE-3 molecule that couples specifically to the binding molecule.A method of using said polypeptide agent to target cells such as functionally exhausted or non responsive immune cells simultaneously expressing inhibitory receptors PD-1 and Tim-3.The compositions and methods are useful for the treatment of chronic immune diseases such as persistent infection or cancer.Selection diagram【課題】二重特異性ポリペプチド剤および多重特異性ポリペプチド剤を含む新規組成物の提供。【解決手段】PD-1分子と特異的に結合する少なくとも1つの結合部位、およびTIM-3分子と特異的に結合する少なくとも1つの結合部位を含む、多重特異性ポリペプチド剤。前記ポリペプチド剤を、阻害性受容体PD-1及びTIM-3を同時発現している機能的に疲弊しているか又は非応答性の免疫細胞のような細胞を標的化するために使用する方法。前記組成物及び方法は、持続感染又は癌のような慢性免疫病の処置のために有用である。【選択図】図１１
