The compounds in contact have pharmacological properties and affect biological activity, pharmaceutical ingredients and use procedures. In particular, Botox derivatives with unique antiviral activity are provided to inhibit the maturation of HIV. These compounds contribute to the treatment of HIV and AIDS. 1. Claim 1: a formula compound (1),including pharmaceutically acceptable salts thereof, wherein R¹ is isopropenyl or isopropyl； A is -Cquil-O-R⁰ alkyl；1. R83044 is heterosexual - q830404；Q⁰ is selected from the group of -H, -CN, -C₁₋₆alkyl,-COOH, pH, o-lessor c832131；-halo, -CF₃；He was chosen from the team-C (O) NR SO R-C (O) NHSO NR R-SO NR C (O) R-tetrazole and -CONHOH； where n = 1-6； R² is -H, -C₁₋₆ alkyl,-C₁₋₆-alkyl substituted with alkyl or -C₁₋₆-alkyl substituted with aryl； W is absent or is -CH₂- or -CO-；R³ is -H, -C₁₋₆-alkyl or -C₁₋₆-alkyl substituted with alkyl； R⁴ is selected from the group of -H, -C₁₋₆alkyl,-C₁₋₆-alkyl-C₃₋₆-cycloalkyl,-C₁₋₆-alkyl substituted with C₁₋₆,-C833218c-83316262-q1 asphalt,-alkyl C₁₋₆-cycloalkyl C₃₋₆-Q¹,Arilo, heterosexual, heterosexual substitution,-SO₂R⁷,-So8322； NR2 and a formula compound (2) or (3),If you are already registered, please log in first.-SO₂- and -NR¹²-；1. In Q1, from c8321c83338326；-fluoroalkyl C₁₋₆,Heteromorphic, heteromorphic substitution, halogen, cf8323,- Oran-Coorrow,-8312； 8313；-CONR R y -SO RR⁵ is selected from the group of -H, -C₁₋₆alkyl,-cycloalkyl C₃₋₆,-C₁₋₆alkyl substituted with alkyl, -Cquilalkyl-NR⁸R⁹,- Ke Lanbo-SO R y -SO NR R2. If r830808 or r830909 is at W sea co -； or2. There is also a condition that only one r83080 or r83099 is elected from the cor8310 group；-Cocoa 8310,-SO R y -SO NR RR⁶ is selected from the group of -H, -C₁₋₆alkyl,-C₁₋₆-alkyl substituted with alkyl, -C₃₋₆-cycloalkyl,-Cyclokquil c8332323-83318326 replace - Q2；-alkyl C₁₋₆-Q²,-C₁₋₆-alkyl substituted with alkyl-Q²,-cycloalkyl C₃₋₆-Q²,Aril-Q2-NR¹³R¹⁴,and -OR¹⁵；Among them, Q2 from arilo, heterosexual, alternative heterosexual,-Coor
