ZEWGE, Daniel,COPELAND, Gregory T.,LI, Zhen,ARMSTRONG III, Joseph, D.
申请号：
AU2018223027
公开号：
AU2018223027A1
申请日:
2018.08.31
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018223027A120180920.pdf#####Abstract This invention relates to the post-synthetic chemical modifications of RNA at the 2'-position in the ribose 5 rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions. RNA interference (RNAi) is an evolutionarily conserved cellular mechanism of posttranscriptional gene silencing found in fungi, plants and 10 animals that uses small RNA molecules to inhibit gene expression in a sequence-specific manner. The RNAi machinery can be harnessed to destruct any mRNA of a known sequence. C: NRPortbl GHMatters MICHELES 10612979_1.docx 30/08/181/70 0la 0 O0f 0 0O0 0 0, 0 ~ 0 0 0 0-: /% = co1 /D t CI m0 0 C. 0 0 0 00 Cif 42QL 0 C4 :m~ = / 0 0cJU 0 / 0 = 00 0? 00 00 0 % 0= %,Q ="0 4 0 _ a00 0 0 <； 0- 0cmI "00
