LY, DANITH H.,THADKE, SHIVAJI A.,PERERA, J. DINITHI R.
申请号：
CA3086551
公开号：
CA3086551A1
申请日:
2018.12.21
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Genetic recognition reagents comprising bivalent nucleobases are provided that bind two strands of nucleic acid, such as an expanded repeat sequence associated with an expanded repeat disease. In one example the expanded repeat disease is a polyQ disease, such as Huntington's disease. Methods of use of the reagents are provided, including a method of binding nucleic acid, such as an expanded repeat sequence associated with an expanded repeat disease, a method of identifying the presence of a nucleic acid comprising an expanded repeat, and a method of treating an expanded repeat disease are provided.
