Vera IVANOVA,Kaoru MAEDA,Wan WANG,Dongwei GUO,Jingjun HUANG
申请号：
US15621844
公开号：
US20170354592A1
申请日:
2017.06.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Carvedilol parenteral sustained release systems by IV infusion, injection, or subcutaneous routes are disclosed. Preparation of carvedilol disperse systems such as liposomes, biodegradable microparticles or nanparticles, and polymeric microparticles or nanparticles have been presented in the present invention. Compositions containing carvedilol encapsulated in liposomes showed higher bioavailability and lower clearance rate than that of the free solution after intravenous administration. In vitro release of those liposomes in buffer solutions shows drug extended release over 48 hours, and correspondingly the in vivo animal data shows that parenteral administration of carvedilol encapsulated in liposomal materials has sustained release PK profile.
