ORJALES-VENERO, AURELIO,BORDELL MARTIN, MARAVILLAS,CANAL MORI, GONZALO,BLANCO FUENTE, HAYDEE,LUCERO DE PABLO, MARIA LUISA,RUBIO ROYO, VICTOR,MOSQUERA PESTAñA, RAMON
申请号：
HRP20041048
公开号：
HRP20041048A9
申请日:
2004.11.09
申请国别(地区):
HR
年份:
2013
代理人:
摘要：
Polymorph 1 of bilastine of the formula (I), which the X-ray crystallographic analysis has the following crystal parameters: crystallographic system: monoclinic； spatial group: P2(1)/c； crystal size: 0.56 x 0.45 x 0.24 mm； cell dimension: a = 2.338 (5) alpha = 90ø, b = 0.8829 (17) nm beta = 90ø, c = 1.259 (2) nm gamma = 90ø； volume 2.6 nm3； Z, calculated density 4, 1.1.84 mg m-3. A process for preparing the polymorph that consists in heating the raw bilastine or polymorphs 2 and 3 of bilastine or a mixture thereof in a solvent selected from short chained alcohols, preferably isopropylic alcohol and n-butanol, acetone and mixtures thereof. The polymorph 1 of bilastine is suitable for antihistaminic and antiallergic use. A pharmaceutical preparation containing this polymorph.Opisan je polimorf 1 4-[2-[4-[1-(2-etoksietil)-1H-benzimidazol-2-il]-1-piperidinil]etil]- α, α-dimetil-benzenoctene kiseline s formulom (I), procedure za njegovu pripravu, farmaceutske formule koje sadržavaju polimorf 1 i upotreba polimorfa 1 za tretiranje alergijskih reakcija i patoloških procesa posredovanih histaminom kod sisavaca kakav je čovjek.njihove smjese, njihove diastereoizomere, njihov postupak pripremanja i farmaceutske strukture koje ih sadrže.
