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FORMES CRISTALLINES ET PROCEDES DE PREPARATION D'AZACYCLES CONDENSES (MODULATEURS DES RECEPTEURS DES CANNABINOIDES)
- 专利权人:
- ARENA PHARMACEUTICALS; INC.
- 发明人:
- BLACKBURN, ANTHONY C.,HAN, SANGDON,JONES, ROBERT M.,MONTALBAN, ANTONIO GARRIDO,PAL, BIMAN B.,RUETER, JAIMIE KARYN
- 申请号：
- CA2827057
- 公开号：
- CA2827057A1
- 申请日:
- 2012.02.24
- 申请国别(地区):
- CA
- 年份:
- 2012
- 代理人:
- 摘要：
- The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)- 1a,2,5.5a-tetrahydro- 1 H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)- 1 - hydroxymcthyl-2.2-dimcthyl-propyl)-amidc (Compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor and are therefore useful in t treatment of CB2 receptor-mediated disorders, for example, osteoarthritis； pain； hyperalgesia； allodynia； inflammatory hyperalgesia； neuropathic hyperalgesia； acute nociception； osteoporosis； multiple sclerosis-associated spasticity； autoimmune disorders； allergic reactions CNS inflammation for example； atherosclerosis； undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcet's disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus； age-related macular degeneration； cough； leukemia； lymphoma； CNS rumors； prostate cancer； Alzheimer's disease； stroke-induced damage； dementia； amyotrophic lateral sclerosis； and Parkinson's disease.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
