Disclosure herein is related to a telemedicine information system. The telemedicine information system includes a monitoring end which receives the physiological signals generated by one or more physiological sensors disposed at the client end over a network. The medical staff uses monitoring terminal device at the monitoring end. The monitoring terminal device is connected with a monitoring server for acquiring the physiological signals since the server periodically retrieves and records the signals generated by the client end's sensors. The signals will be converted to the meaningful information allowing the medical staff to monitor the remote client's physiological condition. The claimed system achieves an efficient remote medical process since the person at the monitoring end may anytime acknowledge the client's condition.