The present invention provides a composition for treating ischemic diseases or neurogenic inflammatory disorders containing a secretome of neural progenitor cells (NPCs) as an active ingredient. The secretome of NPCs of the present invention reduces an ischemic injury site and enables neurological functions to recover by means of roles such as anti inflammation neovascularization regeneration and activation and proliferation of inherent stem cells thereby being usable as a therapeutic agent for ischemic diseases and degenerative nervous system disorders such as nerve damage diseases caused by inflammation. Particularly the secretome of NPCs of the present invention has an excellent behavior improvement effect when administered multiple times.
