The current invention discloses novel uses of orally ingested cobalamins for the maintenance of a healthy and normal body weight and body mass index (BMI). Cobalamins support mitochondrial conversion of carbohydrates into chemical energy called ATP. Cells in the body, especially energy-hungry muscle and brain cells, use ATP as an energy source for many types of cellular functions. Simply put, cobalamins are the natural nutrients needed for cellular metabolism and the burning of calories. In a phase III, placebo-controlled, nutritional study with a total of 1,551 human test subjects, on average those obese people who took cobalamins lost weight and BMI, while those obese people who took placebo gained weight and BMI.