FRIEDLANDER, MARTIN,AGUILAR, HILDA EDITH,DORRELL, MICHAEL I.
申请号：
CA2568750
公开号：
CA2568750C
申请日:
2005.06.06
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention provides compositions and methods of treatingneovascular diseases, such as a retinal neovascular diseases and tumors, byadministering to a patient suffering from a neovascular disease or tumor avascular development inhibiting amount of a combination of the angiogenesissuppressing drugs comprising an angiostatic fragment of tryptophanyl-tRNAsynthetase (TrpRS) and at least one compound selected from the groupconsisting of a vascular endothelial growth factor (VEGF) signaling inhibitorand an integrin signaling inhibitor. Compositions for use in the methodsinclude an admixture of an angiostatic fragment of tryptophanyl-tRNAsynthetase (TrpRS) and at least one of a vascular endothelial growth factor(VEGF) signaling inhibitor and an integrin signaling inhibitor, together witha pharmaceutically acceptable excipient.
