A needle-proof structure (20) and a needle-proof intravenous infusion puncture needle (10). The needle proof structure (20) comprises: a needle holder (22), wherein a first end of the needle holder (22) is used for holding a needle (30)； a needle handle (21), wherein the needle handle (21) is fixed at a second end of the needle holder (22)； a plurality of sliding pieces (23, 24), wherein the plurality of the sliding pieces (23,24) are open-ended tubes intersleeved with each other, with the innermost sliding piece (23) slidably disposed on the needle holder (22), and the total length of the plurality of the sliding pieces (23, 24) along a sliding direction is greater than the length of the needle (30)； a first position-limiting mechanism (25, 26), wherein the first position-limiting mechanism (25,26) can prevent the innermost sliding piece (23) from sliding relative to the needle holder (22), and can also prevent the plurality of the sliding pieces (23, 24) from sliding relative to each other； and a second position-limiting mechanism (232,211), wherein the second position-limiting mechanism (232,211) is disposed at the needle handle (21) and the innermost sliding piece (23), and can prevent the innermost sliding piece (23) from rotating relative to the needle handle (21). The plurality of the sliding pieces sleevingly mounted on the needle holder (22) can provide improved safety and alleviate a pain of a patient. Providing the second position-limiting mechanism (232,211) also prevents the innermost sling piece (23) from rotating relative to the needle holder (22), thereby improving an ease of operation.L'invention concerne une structure étanche de protection pour aiguille (20) et une aiguille de ponction et de perfusion intraveineuse à aiguille de protection étanche (10). La structure étanche de protection d'aiguille (20) comprend : un support d'aiguille (22), une première extrémité du support d'aiguille (22) étant utilisée pour maintenir une aiguille (30)； une poign
