An adenovirus comprising a sequence of formula (I) 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR wherein Βγ comprises a transgene cassette containing four transgenes, said genes encoding a FAP- BITE, CXLI O, CXL9, and IFN. The disclosure also extends to pharmaceutical composition comprising the virus, and use of the virus or formulation is treatment.