ADENOVIRUS ARMED WITH BISPECIFIC T CELL ENGAGER (BITE)

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专利权人:

PSIOXUS THERAPEUTICS LIMITED

发明人:

CHAMPION, Brian,BROMLEY, Alice

申请号：

SG11202001537Q

公开号：

SG11202001537QA

申请日:

2018.08.28

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

An adenovirus comprising a sequence of formula (I) 5′ITR-B1-BA-B2-BX-BB-BY-B3-3′ITR wherein By comprises a transgene cassette containing four transgenes, said genes encoding a FAP-BITE, CXL10, CXL9, and IFN. The disclosure also extends to a pharmaceutical composition comprising the virus, and use of the virus or formulation in treatment.

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