Urszula Grabowska;Lourdes Salvador ODÉN;Magnus Nilsson;Pia Kahnberg;Bertil Samuelsson
发明人:
Lourdes Salvador ODÉN,Magnus Nilsson,Pia Kahnberg,Bertil Samuelsson,Urszula Grabowska
申请号：
US13541519
公开号：
US20120289519A1
申请日:
2012.07.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of the formula II:whereinR1 and R2 are independently H, F or CH3； orR1 forms an ethynyl bond and R2 is H or optionally substituted C3-C6 cycloalkyl；R3 is (optionally substituted) C1-C3 alkyl or C3-C6 cycloalkyl；R4 is methyl or fluoro； m is 0-2；E is optionally substituted thiazolyl；A1 and A2 together define an optionally substituted piperazine or piperidine ring have utility in the treatment of osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
