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neuroregeneration induction method, neuron protection method against neuronal loss or damage, neurodegenerative disease prevention or treatment method due to neuronal loss or damage, and drug candidate screening method for the treatment of neurodegenerative disease
专利权人:
GENUV INC
发明人:
KANG-YELL CHOI,MI-YEON KIM,SUNGHO HAN
申请号:
BR112019009711
公开号:
BR112019009711A2
申请日:
2017.11.23
申请国别(地区):
BR
年份:
2019
代理人:
摘要:
The present invention relates to a method of inducing neuroregeneration comprising administering a mek1 / 2 inhibitor to a patient in need thereof. In the present invention, the mek1 / 2 inhibitor induces neuroregeneration by differentiating neural stem cells into neurons, protecting neural stem cells and neurons against beta-amyloid cytotoxicity, or both of the above. furthermore, the present invention relates to a method of protecting neurons against neuronal loss or damage comprising administering a mek1 / 2 inhibitor. Additionally, this invention relates to a method of preventing or treating neurodegenerative disease due to neuronal loss or damage to patients in need thereof comprising administering a mek1 / 2 inhibitor.a presente invenção refere-se a um método de indução de neuro-regeneração que compreende administrar um inibidor de mek1/2 a um paciente em necessidade do mesmo. na presente invenção, o inibidor de mek1/2 induz a neuro-regeneração diferenciando-se células-tronco neurais em neurônios, protegendo-se células-tronco neurais e neurônios contra a citotoxicidade de beta-amiloides, ou por ambas as alternativas acima. além disso, a presente invenção se refere a um método de proteção de neurônios contra perda ou dano neuronal que compreende a administração de um inibidor de mek1/2. adicionalmente, esta invenção se refere a um método de prevenção ou tratamento de doença neurodegenerativa devido à perda ou dano neuronal para pacientes em necessidade do mesmo que compreende administrar um inibidor de mek1/2.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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