A method of processing images for interventional imaging, wherein a region of interest is visualized, is provided. The method comprises acquiring a series of 2D images of the region of interest in a patient during at least one respiratory phase, acquiring an electrocardiographic signal which is synchronized with the acquisition of the series of 2D images, processing the electrocardiographic signal to estimate at least one deformation phase of the region of interest induced by the patient's respiratory movement, and registering the different successive 2D images in relation to the estimated deformation phase.