The application discloses a dental zirconia restoration material with uniform transition of strength and color, and a preparation method thereof. The preparation method includes the following steps: (1) pouring colored zirconia powder into a dry pressing mould in accordance with a sequence of the strength from high to low and the color from dark to light for each layer, and performing dry pressing; (2) performing isostatic cool pressing after the dry pressing; (3) performing pre-sintering after the isostatic cool pressing to obtain a greenware; and (4) performing CAD/CAM cutting on the greenware, and finally performing final sintering to obtain the dental zirconia restoration material. In the present application, the strength of a restoration can gradually increase from a cut end to the neck, the wear to adjacent teeth and jaw teeth is reduced, and long-bridge restoration can be realized due to the high strength of the neck.