包含莢膜醣結合物之肺炎鏈球菌免疫原組合物、包含其之疫苗及套組及其用途农业专利-农业学术服务平台

发明人:: BIEMANS, RALPH LEON,瑞夫　林恩　毕门斯,瑞夫　林恩　畢門斯,GARCON, NATHALIE MARIE-JOSEPHE,纳萨利　马瑞　乔瑟夫　高肯,納薩利　馬瑞　喬瑟夫　高肯,HERMAND, PHILIPPE VINCENT,菲利普　维森特　赫曼德,菲利普　維森特　赫曼德,POOLMAN, JAN,珍　普尔曼,珍　普爾曼,VAN MECHELEN, MARCELLE PAU,瑞夫林恩毕门斯,瑞夫林恩畢門斯,纳萨利马瑞乔瑟夫高肯,納薩利馬瑞喬瑟夫高肯,菲利普维森特赫曼德,菲利普維森特赫曼德,珍普尔曼,珍普爾曼

摘要：: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided comprising 10 or more capsular saccharides from different S. pneumoniae serotypes which are conjugated to a carrier protein, and comprising 3 or more different carrier proteins, wherein the composition comprises: serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT)； serotype 18C capsular saccharide conjugated to tetanus toxoid (TT)； serotype 1,4,5,6B,7F,9V,14 and 23F capsular saccharides conjugated to protein D from Haemophilus influenzae .本發明揭示一種免疫原組合物，其包含得自血清型19A及19F之肺炎鏈球菌莢膜醣結合物，其中19A與第一細菌類毒素結合且19F與第二細菌類毒素結合。本發明亦描述疫苗、疫苗之製備方法及該等疫苗之用途。