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HETEROARYLO-CYKLOHEKSYLO-TETRAAZABENZO[E]AZULENY JAKO ANTAGONIŚCI RECEPTORA V1A WAZOPRESYNY
专利权人:
F.HOFFMANN-LA ROCHE AG
发明人:
DOLENTE, COSIMO,SCHNIDER, PATRICK
申请号:
PL11714564
公开号:
PL2560975T3
申请日:
2011.04.18
申请国别(地区):
PL
年份:
2015
代理人:
摘要:
The present invention is concerned with heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes of formula I wherein R1, R2 and R3 are as described herein. The compounds according to the invention act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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