HAN, Wen-Ching,STARRETT, John E. Jr.,SCHMITZ, William D.,HUANG, Hong,HILL, Matthew D.,FANG, Haiquan,DEGNAN, Andrew P.,DEBENEDETTO, Mikkel V.,LEE, Francis Y.,VACCARO, Wayne,O'MALLEY, Daniel,GILL, Patri
申请号：
PE2016000945
公开号：
PE20160844A1
申请日:
2014.12.23
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The present invention refers to tricyclic compounds of formula (I) where A is heterocycle, among others； X and Y are H, C1-C6 alkyl, among others； Z is hydrogen, halogen, among others； R1 is hydrogen, halogen, among others； R2 is hydrogen, halogen, among others； R7 is hydrogen, C1-6 alkyl, among others. Preferred compounds are: 2- [3- (dimethyl-1,2-oxazol-4-yl) -5 - [(S) -oxan-4-yl (phenyl) methyl] -5H-pyrido [3,2-b ] indole-7-yl] propan-2-ol； 2- [3- (dimethyl-1H-1,2,3-triazol-5-yl) -5 - [(1S) -4,4,4-trifiuoro-1-phenylbutyl] -5H-pyrido [3,2 -b] indole-7-yl] propan-2-ol； among others. It also refers to a pharmaceutical composition and a method of treatment. These compounds are useful as anticancer.La presente invencion se refiere a compuestos triciclicos de formula (I) donde A es heterociclo, entre otros； X e Y son H, alquilo C1-C6, entre otros； Z es hidrogeno, halogeno, entre otros； R1 es hidrogeno, halogeno, entre otros； R2 es hidrogeno, halogeno, entre otros； R7 es hidrogeno, alquilo C1-6, entre otros. Son compuestos preferidos: 2-[3-(dimetil-1,2-oxazol-4-il)-5-[(S)-oxan-4-il(fenil)metil]-5H-pirido[3,2-b]indol-7-il]propan-2-ol； 2-[3-(dimetil-1H-1,2,3-triazol-5-il)-5-[(1S)-4,4,4-trifiuoro-1-fenilbutil]-5H-pirido[3,2-b]indol-7-il]propan-2-ol； entre otros. Tambien se refiere a una composicion farmaceutica y a un metodo de tratamiento. Dichos compuestos son utiles como anticancerigenos
