A multi-filament flossing instrument which supports more than one flossing filament thereon. The instrument comprises a handle and support frames on which the flossing filaments may be held taut, the support frames fixed to the handle. Filaments may be of different diameters. The instrument may have support frames on each end of the handle, and more than one support frame on each end of the handle. Any support frame may support more than one filament.