Ryan DELLINGER,Troy RHONEMUS,Mark MORRIS,Aron ERICKSON,Haidi CASSER,Marie E. MIGAUD
申请号：
MX2018012849
公开号：
MX2018012849A
申请日:
2017.04.20
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Compositions are provided including nicotinic acid riboside ("NAR"), and derivatives thereof including l -(2',3 ',5'-triacetyl-beta-D-ribofuranosyl)-nicotinic acid ("NAR triacetate" or "NARTA")； or derivatives of a reduced form of nicotinic acid riboside ("NARH"), including 1 - (2',3',5 '-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid ("NARH triacetate" or "NARJT-TA")； or derivatives of nicotinamide riboside ("NR"), including 1 -(2',3',5'-triacetyl- beta-D-ribofuranosyl)-nicotinamide ("NR triacetate" or "NRTA")； derivatives of a reduced form of nicotinamide riboside ("NRH"), including 1-(2',3 ',5'-triacetyl-beta-D-ribofuranosyl)- 1,4- dihydronicotinamide ("NRH triacetate" or "NRH-TA")； or salts or prodrugs thereof, for use in food or beverage applications, pharmaceutical formulations, or as a dietary supplement. Methods of using the compounds above to promote the increase of intracellular levels of nicotinamide adenine dinuc!eotide ("NAD+") or NADH in cells and tissues for improving cell and tissue survival or overall cell and tissue health are provided.Se proporcionan composiciones que incluyen ribósido de ácido nicotínico ("NAR") y derivados de este que incluyen el ácido 1-(2',3',5'-triacetil-beta-D-ribofuranosil)nicotínico ("triacetato de NAR" o "NARTA")； o derivados de una forma reducida de ribósido de ácido nicotínico ("NARH"), que incluyen el ácido 1-(2',3',5'-triacetil-beta-D-ribofuranosil)-1,4- dihidronicotínico ("triacetato de NARH" o "NARH-TA")； o derivados de ribósido de nicotinamida ("NR"), que incluyen 1- (2',3',5'-triacetil-beta-D-ribofuranosil)nicotinamida ("triacetato de NR" o "NRTA")； derivados de una forma reducida de ribósido de nicotinamida ("NRH"), que incluyen 1-(2',3',5'- triacetil-beta-D-ribofuranosil)-1,4-dihidronicotinamida ("triacetato de NRH" o "NRH-TA")； o sales o profármacos de estos, para su uso en aplicaciones para alimentos o bebidas, formulaciones farmacéuticas o como complemento alimenticio. Se proporcionan métodos para
