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proteasome inhibitor
专利权人:
学校法人東京理科大学
发明人:
椎名 勇
申请号:
JP2014084152
公开号:
JP5747394B2
申请日:
2014.04.16
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent. (In the formula, two -(CH 2 ) 1 -N(R 1 )(R 2 ) groups represent a same substituent; R 1 and R 2 each represents a hydrogen atom, or a same or different alkyl group; or alternatively, R 1 and R 2 may combine together to form a monocyclic heterocyclic ring with a nitrogen atom having them or additionally together with one or more atoms selected from an oxygen atom, a sulfur atom and a nitrogen atom; R 3 , R 4 and R S each represents one or more substituents selected from a hydrogen atom, an alkyl group, an acyl group, an alicyclic group, an aromatic group, a halogen atom, an acyloxy group, a cyano group and a nitro group; 1 represents an integer of 2-5; n represents an integer of 1-4; m represents an integer of 1-5; and q represents an integer of 1-3.)
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中国工程科技知识中心
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