PROBLEM TO BE SOLVED: To provide a granular pharmaceutical composition that sufficiently suppresses releasing of a drug in oral cavity and enables fast elution of the drug after transported into a stomach.SOLUTION: The granular pharmaceutical composition comprises a core particle containing a water-swellable substance at the center of the granular pharmaceutical composition, a drug layer containing a drug formed around the core particle, and a layer containing a stomach soluble polymer, around the drug layer.COPYRIGHT: (C)2014,JPO&INPIT【課題】口腔内における薬物の放出を十分に抑制し、および胃内移行後の速やかな薬物溶出を可能にした粒子状医薬組成物。【解決手段】粒子状医薬組成物の中心部に水膨潤性物質を含む核粒子と、その周囲に薬物を含有する薬物層を形成し、さらにその周囲に胃溶性のポリマーを含有する層を有する粒子状医薬組成物。【選択図】なし
