JUERGEN WICHMANN,RAVI JAGASIA,ROLAND JAKOB-ROETNE,SIMONA MARIA CECCARELLI
申请号：
BR112015000313
公开号：
BR112015000313A2
申请日:
2013.08.05
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
patent summary: "piperazine [1,2-a] indol-1-one and [1,4] diazepino [1,2-a] indol-1-one". The present invention relates to compounds of formula (I) wherein R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano； R2 is hydrogen, lower alkyl or lower alkyl substituted by halogen； R3 is phenyl, benzo [1,3] dioxolyl, 2,3-dihydro-benzofuran-5-yl or a 5- and 6-membered heteroaryl, wherein phenyl and 5- and 6-membered heteroaryl groups may be substituted by one or more substituents selected from cyano, nitro, amino and lower alkylamino, lower alkyl sulfonyl, lower alkoxy, halogen substituted lower alkoxy, halogen, lower alkyl, halogen substituted lower alkyl or hydroxyl substituted lower alkyl； x is -ch (lower alkyl) -, -ch2-, -ch2ch2- or -ch (lower alkyl) ch2-； R is hydrogen or lower alkyl； n is 1 or 2； or to a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and / or optical isomers thereof. The compounds may be employed for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-stress disorder. trauma, panic disorder, parkinson's disease, dementia, alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, down syndrome, autistic spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, sclerosis multiple, huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuroactive drugs such as alcohol, opioids, methamphetamine, phencyclidine and cocaine.resumo patente de invenção: "piperazino[1,2-a]indol-1-onas e [1,4]diazepino[1,2-a]indol-1-ona". a presente invenção refere-se aos compostos de fórmula geral (i), em que r1 é hidrogênio, halogênio, alquila inferior, alcóxi inferior, alcóxi inferior substituído por halogênio ou cian
